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As cases of drug -induced hepatic injuries (DILI) are increasing, experts warn the hidden dangers associated with common drugs and supplements.
Statistics show that Dili, also known as toxic hepatitis or hepatotoxicity, which is known to be a significant cause of acute liver failure, has grown in western countries since the 1960’s.
Around one -fifth of the total population prescribed by Dili, according to recent research published in the journal Toxicology Reports.
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The study found that possible triggers of liver injuries include herbs, dietary supplements and medicines.
Those with pre -existing liver conditions and nutritional deficiencies are at higher risk, as well as pregnant women.
As cases of drug -induced liver injury are increasing, experts warn the hidden dangers associated with common drugs and supplements. (Istock)
As medicines can harm the liver
One of the main functions of the liver is to break down the substances taken orally, including supplements and medicines, according to the American College of Gastroenterology (ACG).
For some people, the process of metabolization of these substances may be slower, increasing the risk of liver damage.
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Even the medicines that have been tested for safety and approved by the United States Food and Drug Administration (FDA) can cause liver injury in rare cases, the ACG stated.
The usual symptoms of liver disease include nausea, loss of appetite, abdominal pain, widespread itching, dark urine and jaundice, although some people may not notice signs, according to the previous source.
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Most common drugs that cause dili
The recent study of toxicology reports identified several drugs that are more likely to cause liver injuries.
- Paracetamol (acetaminofen), a retell of common free pain
- Non -steroidal anti -inflammatory drugs (AINE), which are often used to treat headaches, fever and chronic inflammatory disorders
- Aspirin, a common free sale drug used as a fever reducing, pain of pain and thinner
- Nimesulide, an aine used to relieve pain and reduce fever
- Metotrexate, an anti -metabolite drug used to treat rheumatoid arthritis, lymphoma, leukemia and other cancers
- Corticosteroids, which are used to treat conditions that involve inflammation or hyperactive immune systems
- Isoniazid, a first -line treatment for tuberculosis
- Tetracyclines, an antibiotic class that treat multiple types of bacterial infections
- Halothane, used as a general anesthetic during surgical procedures
The turmeric, a common species added to food, has been linked to potential liver toxicity. (Istock)
Supplements related to liver damage
Medicines are not the only agents that can cause drug -induced liver injury.
Dr. Marc Siegel, Fox News Senior Medical Analyst, spoke with Fox News Digital about the risks of herbal and dietary supplements (HDS) that affect the liver.
“The biggest problem of herbal supplements is that the amount you are taking on active chemicals is not strictly regulated, so you don’t know exactly what you are receiving.”
“The biggest problem with herbal supplements is that the amount you are taking on active chemicals is not strictly regulated, so you don’t know exactly what you are receiving,” he said.
“And since some of the supplements are metabolized through the liver, there is now a growing incidence of liver toxicity to users.”
Garcinia Cambogia, a popular weight loss supplement, is among the botanical products commonly used by potential liver toxicity. (Istock)
Dili cases linked to herbal or dietary supplements have tripled almost between 2004 and 2014, according to a 2024 study published in Jama Network Open.
Researchers identified the following most commonly used botanical products known for potential liver toxicity.
- Turmeric, a common species added to food
- Green tea
- Ashwagandha, a grass used for stress and anxiety
- Garcinia Cambogia, a popular weight loss supplement
- Red yeast rice, which is said to help reduce cholesterol levels
- Black Cohosh, a dietary supplement used to relieve menopause symptoms
It is estimated that at least 15.6 million North adults -Americans have used at least one of these six botanical products for the last 30 days.
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“The most involved botanical products in the dilina (network of drug -induced liver injury) include turmeric, kratom, green tea extract and Garcinia Cambogia, with potentially severe and even fatal liver injuries,” the study said.
The researchers noted the liver injuries caused by HDS, even fatal, causing the death or liver transplantation.
Toxic hepatitis or hepatotoxicity – which is known to be a significant cause of acute liver failure – has grown in western countries since the 1960’s. (Istock)
Siegel de Fox News also warned against possible liver risks of some of these named supplements.
“The turmeric is a natural anti -inflammatory and can be useful in small doses, but it can be toxic in large doses,” he warned.
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“Garcinia Cambogia is very popular, especially as a weight loss agent, but there is no real evidence that really works, and there is no reason to take it, especially with new GPP-1 medicines.”
Although red yeast rice has staluts that lower cholesterol, Siegel warned that the number of active chemicals is not as strictly regulated as approved medicines.
“The turmeric is a natural anti -inflammatory and can be useful in small doses, but it can be toxic in large doses.”
“I find it useful in some patients who are reluctant to start statins and look for a more natural alternative, but I have to strictly control the amount taken and the effect on the liver,” he said.
As for green tea, Siegel noted that it has antioxidant properties and it may be useful to consume as a drink (although it has a lot of caffeine) – “but there is no reason to take more in an extract, where it can be toxic.”
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The FDA states on its website that it regulates dietary supplement products and dietary ingredients, but under “a different set of regulations that cover” conventional “pharmaceutical foods and pharmaceuticals.
HDS induced liver injuries can be severe or even fatal, causing death or liver transplantation. (Istock)
“Dietary supplement manufacturers and distributors and dietary ingredients are forbidden to market adulterated or wasteful products,” says the agency. “This means that these companies are responsible for evaluating the safety and labeling of their products before they are commercialized to ensure that they meet all the requirements of the Federal Food, Drug and Cosmetics Act modified by the regulations of DSHEA and FDA.”
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Fox News Digital contacted several researchers and the FDA on increasing liver injury and HSD.
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